Contrast analysis of breast cancer and benign lesion with FCM
- VernacularTitle:乳腺癌及乳腺良性病变的流式细胞术检测对比分析
- Author:
Zhiyong YU
;
Qian GUO
;
Yongsheng WANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
breast cancer;
hyperplasia;
bcl 2;
p53;
flow cytometry
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the mechanism of breast corcinogenesis using breast cancer tissue(BC) , para cancer tissue(PC)), breast hyperplasia(BH)and normal breast tissue(NB) through the measurement of DNA content, S phase fraction (SPF) , bcl 2 and p53 protein expression.Methods:DNA content, SPF , bcl 2 and p53 protein expression were measured on 38 cases BC , 33 cases PC, 20 cases BH and 19 casses NB using flow cytometry (FCM). Results:Our results showed that the ratio of aneuploidy of BC and DI were obviously higher than those of PC,BH and NB respectively ( P
