Expression of uPA,uPAR,PAI-1 in three nasopharyngeal carcinoma cell(NPC) lines with different ability to metastasize
- VernacularTitle:uPA,uPAR,PAI-1在具有不同转移率的鼻咽癌细胞系中的表达
- Author:
Guoqing PAN
;
Yunhong YAO
;
Yuanzhi LU
;
Al ET
- Publication Type:Journal Article
- Keywords:
urokinase;
NPC line and clonal cells;
invasion and metastasis
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression of uPA, uPAR ,PAI 1 in 3 nasopharyngeal carcinoma cell lines CEN 2Z,CEN 2Z H5,CEN 2Z H5 9,with different ability to metastasize through lymph.Methods:RT PCR was used to detect expression of uPA,uPAR,PAI 1 at levels of mRNA.Results:mRNA expression of uPA,uPAR was the highest in CNE 2Z H5 9,whereas the lowest in CNE 2Z;mRNA expression of PAI 1was detected in CNE 2Z and CNE 2Z H5, but revealed no differences,but not in CNE 2Z H5 9.Conclusions:uPA?uPAR may promote the metastasis and invasion of NPC,whereas PAI 1 maybe inhibit it
