Correlation between expression of CD44V6,E-cadherin and biological behavior in breast cancer
- VernacularTitle:CD44v6和E-cadherin表达与乳腺癌生物学行为的关系
- Author:
Huaping GU
;
Peizhong SHANG
;
Yanru LIU
;
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
CD44v6;
E cadherin;
immunohistochemistry
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the relationship of expression of CD44v6, E cadherin (E Cad) with clinic biologicl behavior in breast cancer and its correlation. Methods:Catalyzed signal amplification immunohistochemical method was used to detect the expression of CD44v6 and E Cad in 94 cases of breast cancer.Results:The positive expression of CD44v6 and the negative expression of E Cad were positively correlated with the grading, clinical stage, lymph node metastasis recurrence and prognosis of breast cancer. In breast cancer, the expression of CD44v6 had negative correlation to that of E Cad.Conclusions:Several genes were involved in the occurrence and development of breast cancer in which the expression of CD44v6 had negative regulative synergistic action with that of E Cad. CD44v6 and E Cad expression, as a clinical valuable marker, has a great significance in assessing node metastasis and survival.
