Clinical and pathological significance of transforming growth factor ?1 and its related receptors expressed in human bladder transitional cell carcinomas
- VernacularTitle:TGF?1、T?RⅠ和T?RⅡ在膀胱癌中表达的临床及病理意义
- Author:
Xin YAO
;
Li ZHANG
;
Yanxue LIU
;
Al ET
- Publication Type:Journal Article
- Keywords:
transitional cell carcinoma;
transforming growth factor ?1;
PCNA;
immunohistochemistry
- From:China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the relationships between the biological behavior of human transitional cell carcinomas(TCCs) and the protein expression of transforming growth factor ?1(TGF?1) as well as its'related receptors.Methods:The expression of TGF?1 ,T?RⅠ,T?RⅡ and PCNA were examined in 74 specimens of TCCs by S P immunohistochemistry staining.Results:The positive expression rate of TGF?1 , T?RⅠ and T?R Ⅱ were 89.2%,70.3% and 48.6%,respectively. Superficial tumors had lower overexpression rate of TGF?1 (33.3%) than muscle invasive TCCs (83.8%) ( P
