Biweekly regimen of high-dose leucovorin, fluorouracil and oxaliplatin for advanced and refractory colorectal cancer
- VernacularTitle:高剂量亚叶酸钙、氟尿嘧啶与草酸铂治疗晚期难治性结直肠癌
- Author:
Jianwei LU
;
Liangxi PAN
;
Fulin HUANG
;
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
leucovorin;
fluorouracil;
oxaliplatin;
chemotherapy
- From:China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To evaluate the efficacy and toxicity of the biweekly regimen of high dose leucovorin (CF), continuous central venous infusion(ccvi) of fluorouracil (5 FU) and oxaliplatin (OXA)for advanced and refractory colorectal cancer.Methods:28 patients (12 in rectum,16 in colon) received biweekly CF/5 FU/OXA (CF: 200 mg/m 2,ccvi 2 hour,days 1～2;5 FU:400mg/m 2,iv.,day 1; 5 FU: 1.6 g/m 2,ccvi.22 hours, days 1～2; OXA: 135 mg/m 2,ccvi.4 hour,day 1,every two weeks).Four treatment courses were carried out with an interval of one month.Results:The overall response rate was 39.28%.The response rates of rectal,colonic cancers were 33.33%% and 43.13%, respectively.Median duration of 11 partial responses were 5.0 months.Median survival of all patients was 7.0 months. Median survival of responsive patients,and non responsive was 11.0 and 7.0 months,respectively( P
