5-HT_3 receptor of hippocampus mediate immunomodulation in rat
- VernacularTitle:大鼠海马内5-HT_3受体参与神经免疫调制
- Author:
Shelan LIU
;
Xiaoyu ZHANG
;
Deyi XU
;
- Publication Type:Journal Article
- Keywords:
Hippocampus Neuroimmunomodulation 5 HT 3 receptor Splenocytes Proliferation response
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The study is designed to explore the neuroimmunomodulation mediated by 5 HT 3 receptor of hippocampus in rats.Methods:ConA or lipopolysaccharide stimulated splenocytes proliferative responses are measured by TdR incorporation.Results:1 phenylbiguanide(PBG) 1 mg/kg,ip,10 ?g,icv and microinjection in the ventral hippocampus could enhance the splenocyte proliferative responses stimulated by ConA and LPS in mice and rats respectively.But the inhibitory effect on ConA stimulated response was only obtained by bilateral microinfusion of PBG in the dorsal hippocampus,while had no effect on the LPS induced proliferative responses.All of effects on mitogen stimulated splenocyte proliferation could be antiagonized by coadministration of a selective 5 HT 3 antiagonist tropisetron.Conclusion:It suggested that the 5 HT 3 receptors in the hippocampus might mediate neuro immuno modulation in which ventral and dorsal hippocampus have different effects.
