Experimental study on inducing apoptosis of tumour cells by protamine inhibiting angiogenesis
- VernacularTitle:鱼精蛋白抑制血管生成诱导肿瘤细胞凋亡的实验研究
- Author:
Longjiang LI
;
Yuming WEN
;
Changmei WANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
malignant tumour;
protamine;
inhibiting angiogenesis;
apoptosis
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the therapeutic mechanism through inducing apoptosis of tumour by protamine inhibiting angiogenesis . Methods:The vascular density and apoptotic index(AI)in the tumour were investigated by immunohistological and Tunel(terminal deoxynucletidy1 transferase-mediated dU TP nick end-labelling) methods in animal tumour model with experimental treatment. Results:The vascular density of tumour was much lower in controls. Apoptosis appeard in the treated group and AI is (7.67?1.70)%. Conclusions:Protamine could reduce the vascular density of tumour very much and induce the apoptosis of tumour cells. The therapeutic effects were achieved by inhibiting angiogenesis and inducing apoptosis of tumour.
