Calcium folinate, 5-fluorouracil bolus and continuous infusion combined with cisplatin in advanced esophageal carcinona
- VernacularTitle:CF加5-FU持续滴注联合DDP治疗晚期食管癌
- Author:
Yi JIANG
;
Yuxian YANG
;
Xianghua XU
;
Al ET
- Publication Type:Journal Article
- Keywords:
advanced esophageal carcinoma;
calcium folinate;
chemotherapy;
5 fluorouracil;
cisplatin
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: The aim of this study is to assess the anti tumor efficacy and safety of high dose folinic acid plus 5 fluorouracil bolus and continuous infusion 48 hours combined with cisplatin in treating advanced esophageal carcinoma. Methods:Thirty patients with advanced esophageal carcinoma were treated with high dose folinic acid plus 5 fluorouracil bolus and continuous infusion 48 hours combined with cisplatin.Results: There were two complete responses, fourteen partial responses, thirteen no changes and one progressive disease in this series with total response rate of 53.33%. The main side effects include nausea and vomiting, mucositis, bone marrow suppression and alopecia. Other side effects were uncommon. All side effects were tolerable and mild except for nausea vomiting. Conclusions: High dose folinic acid plus 5 fluorouracil bolus and continuous infusion 48 hours combined with cisplatin may be a safe and effective therapy for the patients with advanced esophageal carcinoma.
