Urinary telomerase activity in the diagnosis and recurrence screening of bladder carcinoma
- VernacularTitle:尿液端粒酶活性在膀胱癌诊断和监测复发中的意义
- Author:
Shaobo YANG
;
Zhenhua LI
;
Lizhong WANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Diagnosis;
Recurrence;
Telomerase
- From:
Chinese Journal of Urology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of urinary telomerase activity (TA) in the diagnosis and recurrence screening of bladder carcinoma. Methods TA in urine of 46 cases of superficial bladder carcinoma and 46 normal subjects was estimated by the method of PCR ELISA, and it was monitored continuously in 20 cases after transurethral resection of tumors. Results TA in urine of patients with bladder carcinoma increased significantly as compared with the controls.It dropped to normal range after tumor removal, but rose again with tumor recurrence.The specificity and sensitivity of TA detection were 93.5% and 47.8% respectively. TA was positively related to the grade of tumors whereas there was no association between the preoperative value of TA and early recurrence. Conclusions The examination of TA in urine is helpful for the diagnosis of bladder carcinoma and it is related to the differentiation degree of tumors.It may become an important supplement to cystoscopy in the screening of tumor recurrence.
