Expression of membrane complement regulatory protein on the surface of CD16~+ monocyte/macrophage and level of C3d in the blood of patients with glomerulonephritis
- VernacularTitle:肾炎患者血中C3d水平及CD16~+单核巨噬细胞膜补体调节蛋白的表达
- Author:
Hongxiang LI
;
Qiuhuan LI
;
Jiyun ZHANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis Membrane complement regulatory protein C3d C3d IC
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of membrane cofacto protein(MCP)?decay accelerating factor(DAF) and homologous restricition factor 20(HRF 20) on the surface of CD16 + monocyte/macrophage(Mo/M?) in patients with glomerulonephritis(GN).Methods:Tested the expression levels of MCP?DAF and HRF 20 on the surface of CD16 +Mo/M? by Flow Cytometry and the levels of serum C3d and C3d immunologic complex(C3d IC) by ELISA in 136 patients with GN,divided into mini change(MC)?glomerulosclerosis(GS)?membranous nephropathy(MN) and proliferative glomerulonephritis(PGN).Results:The expressions of MCP?DAF and HRF 20 on the surface of CD16 +Mo/M? and the serum levels of C3d in the patients with GS?MN or PGN were significantly higher than those in controls(P
