Effect of IL-6、IL-1?、TNF? on the Growth of Human Fetal Cerebral Neurons in vitro
- VernacularTitle:IL-6、IL-1?、TNF?对人胎大脑神经细胞体外生长的影响
- Author:
Langying LI
;
Jiao WEI
;
Xueqian YIN
;
Al ET
- Publication Type:Journal Article
- Keywords:
Cytokine Cerebral neuron of human fetal Growth and differentiation
- From:
Chinese Journal of Immunology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of Il 6?IL 1??TNF? on the growth and development of cultured human fetal cerebral neurons.Methods:Established the model of primary culture of human fetal cerbral neurons in SFFD,by morphological observation and MTT assay.Results:IL 6 and IL 1? both promote the survival of neurons and IL 6 also promote the outgrowth of neuritis and differentiation of neurons in culture.TNF ? continuously inhibit the survival of neurons.Conclusion:IL 6?IL 1??TNF? can effect the development of cultured neurons.IL 6 and IL 1? both may effect as neurotrophic factor in the survival?growth and development by indirect mechanism.TNF? directly show neurotoxin effect in culture.
