Effect of cyclophosphamide pulse therapy on levels of serum interleukin-6 in patients with lupus nephritis
- VernacularTitle:环磷酰胺冲击疗法对狼疮性肾炎血清IL-6的影响
- Author:
Xingzhong FAN
;
Xindong LI
;
Baoan PAN
;
Al ET
- Publication Type:Journal Article
- Keywords:
Lupus nephritis Interleukin 6 Cyclophosphamide
- From:
Chinese Journal of Immunology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate role of interleukin 6(IL 6) in the pathogenesis of lupus nephritis(LN) and effect of cyclophosphamide pulse therapy on production of IL 6.Methods:Serum IL 6 levels of pre and post therapy were determined by using sandwich ELISA in LN patients.Results:In the active LN patients,serum levels of IL 6 were significantly higher than those in inactive LN patients and healthy controls(268.26?79 64 ng/L vs 62.40?45 23 ng/L,268 26?79 64 ng/L vs 50.36?42 75 ng/L,P16 g/L were significantly higher than those in other active LN patients (329.58?94.21 ng/L vs 233.22?43.56 ng/L,P
