Expression of telomerase and p53,p16 genes and its significance in non-small-cell lung cancer
- VernacularTitle:端粒酶与p53、p16基因在非小细胞肺癌中的表达及其意义
- Author:
Baijun CHENG
;
Shun LU
;
Jiuxian FENG
;
Al ET
- Publication Type:Journal Article
- Keywords:
non small cell lung cancer;
telomerase;
p53;
p16
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression of telomerase,p53 and p16 genes in non small cell lung cancer(NSCLC). Methods:The expression of telomerase, p53 and p16 genes were examined in 40 NSCLC cases by SP and TRAP methods, respectively. Results:The positive expression rates of telomerase,p53 and p16 genes in NSCLC were 92.5%, 37.5% and 66.7%, respectively. The positive expression rate of p53 gene correlated closely with the T and pathological staging of NSCLC ( P 0.05). Telomerase activity was correlated with the expression rate of p53 gene and pathological stages but negatively correlated with the ages of NSCLC patients( P
