Advances in diagnosis and treatment of hereditary nonpolyposis colorectal cancer
- VernacularTitle:遗传性非腺瘤病性结直肠癌的诊治进展
- Author:
Ye XU
;
Sanjun CAI
;
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
hereditary nonpolyposis;
diagnosis;
treatment
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Hereditary nonpolyposis colorectal cancer (HNPCC) is a distinct autosomal dominant syndrome, accounting for 5%-10% of the total colorectal cancer population. To date, we have noticed that patients with HNPCC inherit a germline mutation in one of the genes responsible for repair of DNA mismatch errors. Tumors of HNPCC show a high frequency of microsatellite instability. Identifying individuals afflicted with HNPCC has implications for surgical management, prognosis, follow up, and surveillance of HNPCC patients and family members at risk.
