Role of IL-10 in acute graft-versus-host disease and graft rejection
- VernacularTitle:IL-10在急性移植物抗宿主病、移植物排斥中的作用
- Author:
Xiaoping JU
;
Jianmin WANG
;
Weiping ZHANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
IL 10 Acute graft versus host disease Graft rejection
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study role of IL 10 in acute graft versus host disease(aGVHD)and graft rejection.Methods:20 patients undergoing allogeneic hematopoietic stem cell transplantation (allo HSCT),serum concentrations of IL 10 were measured by using enzymed linked immunosorbent assay(ELISA)during transplantation,IL 10 gene expression in peripheral mononuclear cells were measured by using reverse transcriptase polymerase chain reaction (RT PCR)after transplantation.Results:6 patients developed grade I GVHD.4 patients grade III IV GVHD,3 patients graft rejection. Before transplantation ,the concentrations of IL 10 with the patients who developed severe aGVHD or graft rejection were lower than those without aGVHD.After transplantation, the concentrations of IL 10 with the patients who developed severe aGVHD or graft rejection decreased,and those without aGVHD or graft rejection significantly increased. The result of RT PCR suggested that the expression of IL 10 mRNA decreased in the patients who developed aGVHD.Conclusion:IL 10 plays an important negative role in the development of aGVHD and graft rejection.
