Effects of tripter gium wilfordi on urine mononeuclear cells and CD44 expression in patients with IgA nephropathy
- VernacularTitle:雷公藤多甙对IgA肾病尿液单个核细胞分布和CD44表达的影响
- Author:
Jianhui YANG
;
Yanxia WANG
;
Jiyun ZHANG
;
- Publication Type:Journal Article
- Keywords:
IgA nephropathy Triptergium wilfordi Cell immunity CD44 Cytoflowmetry
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the possible therapeutic mechanisms of triptergium wilfordi in treating glomerulonephritis.Methods:Thirty seven patients with IgA nephropathy were detected urine mononeuclear cells densities with flow cytometry during taking triptergium wilfordi tablets,30 healthy people were used as normal control.Results:The patients urine CD3 +?CD4 +?CD8 +?CD14 + and CD44 + cells densities were much higher than normal control's,but obviously decreased after triptergium wilfordi treatment.CD4/CD8 ratio was much lower in patients than in normal control.It increased markedly after treatment.Patients who reached remission initially had a lower CD4 + cell percentage and higher CD14 + cells percentage than those showed no response to triptergium wilfordi treatment.Conclusion:Triptergium wilfordi could modulate kidney immune cell function and adhesive molecule CD44 expression.Its effects were associated with renal immunity.
