The study of dendritic cell phenotypic antigens in human ovarian epithelial carcinoma
- VernacularTitle:树突状细胞表型抗原在人卵巢癌组织中的表达
- Author:
Yinsheng LI
;
Suying LEI
;
Yan DAI
;
Al ET
- Publication Type:Journal Article
- Keywords:
CD1c S 100 Dendritic cell Ovarian carcinoma
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the numbers and distributions of dendritic cells and the expressive intensity of CD1c,S 100 in different human ovarian carcinoma tissues,and to discuss the relationship between them and the mechanism of development.The study can provide the experimental date of biological therapy of ovarian carcinoma.Methods:The samples of 31 patients with ovarian carcinoma were analyzed by ABC immunocytochemistry and computer imaging techniques.Results:The results showed that the number of positive dendritic cells in ovarian carcinoma reduced greatly with significant and the expressive intensity of CD1c,S 100 was weaker in ovarian carcinoma than in normal ovarian tissues.Conclusion:The total expression of dendritic cells phenotypic antigens was reduced in ovarian epithelial carcinoma,which may play an important role in initiating immunity against ovarian carcinoma.
