The preliminary study on the effect of CTLA4-Ig on T cell function and its mechanism
- VernacularTitle:CTLA4-Ig影响T细胞功能及机理的初步研究
- Author:
Yu ZHENG
;
Yan LI
;
Beifen SHEN
;
Al ET
- Publication Type:Journal Article
- Keywords:
CTLA4 Ig Activation of T cell RE/AP
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the inhibited function of CTLA4 Ig on T cell activation and its mechanism Methods:After separating fresh PBMC,the effects of CTLA4 Ig on T lymphocyte transformation and mixed lymphocyte reaction were analyzed,and its inhibitory effect on the CD25 expression on T cell surface was observed At last,the changes of the nuclear protein in active T cell were analyzed by the EMSA method.Results:CTLA4 Ig has an inhibitory effect on the lymphocyte transformation,MLR and CD25 expression on T cell surface,and it can inhibite the activation of RE/AP binding factor related to IL 2 expression. Conclusion:CTLA4 Ig inhibit the activation of T cell by multipathway,one of the mechanism might be its inhibitory effect on the activation of RE/AP binding factor.
