Oxidation Damage of Sulfur Dioxide Inhalation on Erythrocytes of Rats
- VernacularTitle:二氧化硫吸入对大鼠血红细胞的氧化损伤作用
- Author:
Ziqiang MENG
;
Bo ZHANG
;
- Publication Type:Journal Article
- Keywords:
Sulfur dioxide;
Bisulfite;
Antioxidative enzymes;
Lipid peroxidation;
Reactive oxygen species
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aims of the present study are to further investigate mechanism of toxicological role of sulfur dioxide (SO 2) exposure on mammalian animals Methods Effects of SO 2 inhalation (14 mg/m 3) on activities of antioxidative enzymes and levels of lipid peroxidation in erythrocytes of male rats were determined Results SO 2 inhalation caused the decrease of Cu,Zn SOD activity,the increase of GSH Px activity,and no change of CAT activity,and the increase of level of lipid peroxidation in rat erythrocytes Conclusion Primary mechanism of toxicological role of SO 2 exposure at low concentrations may be that oxidation damages of lipid and other biological large moleculars are caused by SO 2 producing reactive oxygen species
