ANTIANGIOGENESIS STUDY OF ROQUINIMEX IN TREATMENT OF HUMAN COLORECTAL CANCER
- VernacularTitle:Roquinimex治疗人大肠癌的抗血管生成作用研究
- Author:
Oucheng WANG
;
Da YU
;
Lirong CHEN
;
Al ET
- Publication Type:Journal Article
- Keywords:
Roquinimex;
Colorectal cancer;
Antiangiogenetic effect
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the antiangiogenetic ability of Roquinimex for human colorectal cancer in vivo,and to study the possible mechanism of Roquinimex.Methods:The transplanted model of human colorectal cancer in nude mice was established and the effection of various doses of Roquinimex were compared.The microvesssal density (MVD) in tumor tissue of nude mice was accounted by immunohistochemical method.We also observed the antiangiogenesis effection of Roquinimex for chick embryo chorioallantic membrane (CEM).Rusults:Roquinimex did inhibit the growth of SW1116 in nude mice.In all doses of Roquinimex treated group,the masses were less than that in control group ( P
