PRELIMINARY STUDY ON THE EXPRESSION OF SURVIVIN PROTEIN IN CERVICAL INTRAEPITHELIAL NEOPLASIA AND CERVICAL CARCINOMA
- VernacularTitle:Survivin在宫颈上皮内瘤样变及宫颈癌中表达的初步研究
- Author:
Mei WANG
;
Bing WANG
;
Xiaoli WANG
;
- Publication Type:Journal Article
- Keywords:
Survivin gene;
Cervical intraepithelial neoplasia;
Cervical carcimoma;
Immunohistochemistry
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of survivin gene in cervical carcinoma and its relation to the pathogenesis of cervical carcinoma.Methods:Using SP immunohistochemical technique,we examined 74 cervical tissues of clinicopathological specimens,including 10 normal cervical tissues,5 cervical intraepithelial meoplasia(CIN)lesions,59 invasive squamous cell carcinomas.Rusults:Expression of survivin were not observed in normal cervical tissues. With the lesions progressing ,the expression rate of survivin protein had a increasing tendency.Expression of survivin was related to the tumor grade and clinical stage.Conclusion:The results suggested that survivin expression is the essential event in carcinogenesis and development of cervical carcinoma.Survivin expression in cervical carcinoma is a useful prognostic marker.
