TELOMERASE ACTIVITY AND DNA PLOIDY IN GASTRIC CARCINOMA AND ITS CLINICAL SIGNIFICANCE
- VernacularTitle:胃癌端粒酶活性与DNA倍体的关系及临床意义
- Author:
Donghua LI
;
Zhongling XIA
;
- Publication Type:Journal Article
- Keywords:
Gastric neoplasms;
Telomerase;
DNA;
Aneuploidy
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between telomerase activity and DNA ploidy in gastric carcinoma.Methods:Telomerase activity was detected using telomerase repeat amplification protocol(TRAP),and image cytometry(ICM) was used to examine the DNA ploidy.Rusults:The total positive rate of telomerase in gastric carcinoma was 81.25%.The telomerase positive rate in early stage and advanced stage were 55.5% and 87.2% respectively.Aneuploid tumors tend to be telomerase positive.Conclusion:The telomerase activity is correlated with the progression and aneuploid rate in gastric carcinoma.
