STUDY ON THE EXPRESSION OF IN SITU C myc,N ras ONCOGENES AND HEPATITIS B VIRUS INFECTION IN HEPATOCELLULAR CARCINOMA IN GUANGXI
- VernacularTitle:广西地区肝细胞癌中c-myc和N-ras癌基因的原位表达与HBV感染关系的研究
- Author:
Xiaoxian DUAN
;
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
myc;
ras;
Gene expression;
HBxAg
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyse the relationship between the expression of c myc,N ras oncogenes and hepatitis B Virus(HBV)infection in hepatocellular carcinoma(HCC) in Guangxi and the roles of these factors in hepatocarcinogenesis.Methods:c DNA RNA ,N ras mRNA,HBsAg and HBxAg in 40 cases of HCC and their adjacent liver tissues were studied.Rusults:The expression of c myc,N ras oncogenes were very high in HCC and their adjacent live tissues.Their positive rates were all over 85%.No significant difference of the two oncogenes′ expression among different grades of HCC was found.The positive rates of HBsAg and HBxAg were 87.09% and 79.31% respectively.The detections of oncogenes were parallel to the detections of HBsAg and HBxAg.Conclusion:c myc and N ras might be involved in the formation and maintenance of HCC.They may be activated by HBxAg.
