Human follicular dendritic cells increase HIV infection
- VernacularTitle:人类滤泡树突状细胞增强HIV的感染
- Author:
Yongjun JIANG
;
Hong SHANG
;
Yanan WANG
;
- Publication Type:Journal Article
- Keywords:
Human follicular dendritic cell HIV Infection
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Study on the possibility that human follicular dendritic cells(FDC) can increase HIV infection and to investigate the related mechanisms.Methods:Human FDC was isolated from tonsils and cultured with infected heterogenous pheripheral lymphocytes or cultured with infected hemogenous tonsilar T lymphocytes.HIV P24 antigen,HIV 1 env DNA and HIV 1 nef RNA were determined respectively with ELISA method,PCR or RT PCR method.Results:FDCs were cultured with infected heterogenous lymphocytes,the P24 antigen is 6 7 times higher than the control group(P
