Association between the level of Bcl-2 expression in EBV-LCLs and the sensitivity of NK's cytotoxicity to EBV-LCLs
- VernacularTitle:EBV-LCLs内Bcl-2水平与其对NK胞毒作用敏感性的相关性研究
- Author:
Chongyun FANG
;
Xiongwen WU
;
Kaiyan WANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Bcl 2 Oligodeoxynucleotide NK cytotoxicity Apotosis
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the level of Bcl 2 protein in EB virus infected cells and the sensitivity of this cells to NK activity and apoptosis inducing factors.Methods:Antisense oligodexynucleotides(ODNs) were used to modulate the expression of Bcl 2 gene in Epstein Barr virus transformed B lymphoblastoid cell lines(EBV LCLs);then the change of cytotoxicity of natural killer cells and the sensitivity of apoptosis inducing elements(taking out growth factor ?dexamethasone)targeting EBV LCLs,were investigated.Results:The level of Bcl 2 expression in EBV LCLs has negative relativity with the cytotoxicity of NK cells to EBV LCLs(P
