Expression of E-cadherin and nm23 in papillary thyroid carcinoma and its clinical significance
- VernacularTitle:E-cadherin、nm23在甲状腺乳头状腺癌中的表达及其临床意义
- Author:
Detao YIN
;
Ling WANG
;
Qingzhao WANG
;
- Publication Type:Journal Article
- Keywords:
thyroid neoplasm;
epithelial cadherin;
nm23;
immunohistochemistry
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the expression of E cadherin and nm23 in papillary thyroid carcinoma (PTC) and its clinical significance. Methods:The expression of E cadherin and nm23 were detected by SP immunohistochemical technique in 70 paraffin embedded tissue specimens of PTC.Results:The positive rates of E cadherin and nm23 were 44.3%(31/70) and 62.9%(44/70) respectively. There were close relations between the expression of E cadherin and nm23 and pathological grade, TNM stage and lymph node metastasis, and no difference could be found between the expression of E cadherin and nm23 and size of tumor, sex and age of patients. There was distinct correlation between the expression of E cadherin and nm23. The metastatic rate in the group, which the expression of E cadherin and nm23 were both positive, was 12%(3/25), but in the all negative group, the metastatic rate was 75%(15/20). There was significant difference between the two groups ( P
