Dendritic cells activated by tumor antigen to treat bladder tumor in mouse
- VernacularTitle:捕获肿瘤抗原的树突状细胞治疗小鼠膀胱肿瘤
- Author:
Renfu CHEN
;
Shulian XIE
;
- Publication Type:Journal Article
- Keywords:
dendritic cells;
bladder tumor;
granulocyte macrophage colony simulating factor;
immunotherapy
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the feasibility of GM CSF and the tumor antigen activated dendritic cells in treating bladder tumor in rats.Methods:The DCs isolated from the spleen of T739 mice which were stimulated in vitro by syngenic granulocyte macrophage colony stimulating factor (GM CSF) and irradiated inactivated BTT739 Bladder tumor cells(Group D),were transfused intravenously once a week when BTT739 tumor cells were inoculated in mouse. Group A was established as control,group B and C were injected with GM CSF activated DCs and inactivated tumor vaccine.Results:In group D, the CTL activity against the BTT739 tumor and cytokine IL 4 and IFN ? was significantly higher than those in other groups ( P
