The detection of specific antibodies in tears of guinea pigs after immunized with two bivalent Shigella vaccine strains(Ipa~+/Ipa~-)
- VernacularTitle:双价痢疾菌苗角结膜免疫豚鼠后泪液中特异性抗体的检测
- Author:
Xinfu SHI
;
Li XING
;
Zhihua CHEN
;
Al ET
- Publication Type:Journal Article
- Keywords:
Ipa Bivalent Shigella vaccines Specific antibodies
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the influence of Ipas, and construct better Shigella vaccines.Methods: Guniea pigs were immunized with Ipa + and Ipa - bivalent Shigella vaccines strains by eyes mucosal immunization, and challenged with willed strains. The specific antibodies in tears were measured by BA ELISA assays after immunization and challenge. Results: The levels of specific local specific antibodies of immunized groups increased significantly compared to the control group and Ipa + group compared to Ipa - group after immunization.Conclusion: The expression of invasive plasmid antigens(Ipa) can enhance the levels of specific local antibodies. The two Shigella vaccines have good immunogenicity.
