The modulation of expression of adhesion molecules ? integrins and L-seletin on CD34~+ cells during peripheral blood mobilization with cytotoxic chemotherapy and G-CSF
- VernacularTitle:外周血干细胞动员调节CD34~+细胞?整合素及L-选择素的表达
- Author:
Shaokai LUO
;
Xiuzhen TONG
;
Wende HONG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Cytotoxic chemotherapy G CSF Mobilization CD34 + cells Adhesion molecule
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study whether the mobilization process is associated with change in expression of adhesion molecules on CD34 +cells Methods:Two colour fluorescence analysis was used to study the expression of adhesion molecule CD62L,CD49d,CD11a,CD11b on CD34 + cells of peripheral blood stem cells(PBSC) before and after mobilizing with G CSF and cytotoxic chemotherapy in 15 cancer patients undergoing PBCST Results:① The expression of adhesion molecules on CD34 +cells revealed a significant reduction of CD11a, CD49d and CD62L at days 7 compared to the baseline level (P
