Effects of Hydrolysis and Polymerization of Aluminum Salt in Water Solution on Developmental Toxicity in Rats in Vitro.
- VernacularTitle:铝盐在水溶液中的水解和聚合反应对铝致大鼠发育毒性的影响
- Author:
Benzhong ZHANG
;
Weidong QU
;
Desheng WU
;
- Publication Type:Journal Article
- Keywords:
Aluminum;
Whole embryo culture;
Developmental toxicity
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of chemical reaction of aluminum salt in water solution on developmental toxicity Methods Inhibiting actions on embryo growth and development,and organ morphogenetic differentiation in rats induced by newly prepared and 11 5 month stored aluminum sulfate solution were observed and compared using whole embryo culture method in rats Results Both of the two observed solutions showed a certain embryo toxicity and teratogenicity The toxicity of stored solution decreased significantly compared with that of newly prepared solution At the same concentration of aluminum,the total Brown's morphogenetic score reflecting the every index of embryo growth and development and organ morphogenetic differentiation,the incidence rates of terata and the number of dead embryos were significant lower in rats exposed to stored solution compared with those exposed to newly prepared solution,especially the morbidity of embryos Conclusion The complexation reaction between aluminum ions (Al 3+ ) and water molecules in stored aluminum sulfate solution resulted in the changes of existing state of Al 3+ and its decreasing developmental toxicity to rats
