EXPRESSION AND RELATIVITY OF CYCLIND 1 IN THE BIOLOGICAL BEHAVIOUR OF TEANSITIONAL CELL CARCINOMA OF BLADDER
- VernacularTitle:cyclinD_1表达与膀胱移行细胞癌生物学行为关系的研究
- Author:
Xu SONG
;
Yuangeng SUI
;
Hongfei WU
;
- Publication Type:Journal Article
- Keywords:
Bladder neoplsma;
Transitional cell carcinoma;
CyclinD 1;
Immunohistochmistry
- From:
Cancer Research and Clinic
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression and significance of cyclinD 1 in 45 cases of transitional cell carcinoma of bladder.Methods:The expression of cyclinD 1 was detectde by immunohistochemistry(SP).Results: Expression of cyclinD 1 was found in 55.56% of TCCs and none of controls,and 78.57% of T a～T 1,11.76%of T 2～T 4.Approximately,85% of G 1,46.67% of G 2 and 10% of G 3 with the progress of tumors clinical stages and grades ,and the positive rates of cyclinD 1 expression decreased. There was no significant correlation between cyclinD 1 expression and number of lesions and postoperative reccurance.Conclusions: CyclinD 1 overexpression can play an important role in the early stage of bladder tumorgenesis.There was significant relativity between cyclinD 1 expression and the biological behaviour of bladder TCCs.
