The mechanism of anti-CD4 antibodies inhibitory effect on SEB-induced PBMC proliferation
- VernacularTitle:抗CD4抗体对SEB诱导的PBMC增殖反应的抑制作用机理
- Author:
Zhihong ZHANG
;
Guanxin SHEN
;
Jing YANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Chimeric antibodies Murine McAbs The inhibitory effect on proliferation CD4 +T cells Apoptosis
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mechanism of anti CD4 antibodies effect on SEB induced proliferation of the peripheral blood mononuclear cells (PBMC) Methods:Using MTT method to observe anti CD4 antibodies effect on PBMC proliferation in different conditions Using morphologic, biochemistry and flow cytometer methods to detect CD4 +T cells apoptosis induced by anti CD4 antibodies Results:Both anti CD4 human/murine chimeric antibodies and murine McAbs could inhibit the SEB induced PBMC proliferation Anti CD4 chimeric antibodies could specially induced CD4 +T cells apoptosis Conclusion:Most important inhibitory effects of the anti CD4 antibody appear to direct at TCR induced early activation signals, and their inhibitory effect of anti CD4 chimeric antibodies is close related to the monocytes The further cross linking of anti CD4 antibodies is important for inducing CD4 +T cells apoptosis
