Maternal Toxicity in Rats Induced by Exposure to Methylmercury DuringPregnancy
- VernacularTitle:妊娠期甲基汞暴露对大鼠的母体毒性
- Author:
Jian LI
;
Ping LIU
;
Dongquan NA
;
Yuming MAO
- Publication Type:Journal Article
- Keywords:
Methylmercury;
Maternal toxicity;
Reproductive toxicity
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the maternal toxicity in Wistar rats induced by exposure to methylmercury in rats during pregnancy Methods The parameters of physiological development,reproductive process and brain histomorphology were observed and monoamine neurotransmitters(noradrenaline,dopamine and 5 HT) were determined during pregnancy and lactation periods,continuous oral perfusion with methylmercury with different concentrations of 0 00,0 01,0 05 and 2 00 mg/(kg?d) was performed during the 6th~9th day after conception to terminal pregnancy Results The levels of monoamine neurotransmitters in brain tissue of maternal rats in exposure groups increased significantly compared with those in control group(P
