Preliminary study on antitumor effect of C_( 215) gene transfected tumor vaccine and monoclonal antibody-superantigen fusion protein C_(215) Fab-SEA
- VernacularTitle:C_(215)抗原基因转染的瘤苗联合单抗与超抗原的融合蛋白C_(215)Fab-SEA的抗肿瘤作用初步研究
- Author:
Qingqing WANG
;
Hai YU
;
Da YU
;
- Publication Type:Journal Article
- Keywords:
Tumor vaccine Fusion protein Antitumor effect
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the anti tumor effect of C 215 gene transfected tumor vaccine and monoclonal antibody superantigen fusion protein C 215 Fab SEA.Methods:B16 melonoma cells were transfected with the gene encoding a human colon adenocarcinoma cell surface glycoprotein C 215 to produce a tumor vaccine,melanoma models were established in C57BL/6 mice to observe the antitumor effect of the tumor vaccine and the fusion protein C 215 Fab SEA.Results:Tumor growth in mice treated with the vaccine together with the fusion protein C 215 Fab SEA was significantly inhibited compared with the control group(P
