Regulation of external LIF on the expression of integrin ?_3 in the mouse endometrium during peri-implantation period
- VernacularTitle:外源性LIF和IL-1对围着床期小鼠子宫内膜整合素?_3亚基表达的调节
- Author:
Wei ZHANG
;
Jianping ZHOU
;
Yinkun LIU
;
Al ET
- Publication Type:Journal Article
- Keywords:
Leukemia inhibitory factor Interleukin 1 Integrin ? 3 Endometrium Implantation
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study regulation of external leukemia inhibitory factor(LIF) and interlukin 1(IL 1) on the expression of integrin ? 3 in the mouse endometrium during peri implantation period and explore the mechanism which LIF participate in embryonic implantation.Methods:The mice were injected peritoneally with LIF,IL 1 or IL 1ra at different administration on day 2～4 of pregnancy.The level of integrin ? 3 protein was measured with Westernblot method and mRNA measured with RT PCR.Results:The levels of integrin ? 3 protein and mRNA were increased by LIF and IL 1(P
