The correlation of p53 and nm23 expression with invasiveness and metastasis in colorectal carcinoma
- VernacularTitle:p53和nm23蛋白表达与大肠癌浸润转移的关系
- Author:
Lijuan XUE
;
Weizhong WANG
;
Wenlan ZHANG
;
Pu YIN
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma Gene expression Immunohistochemistry p53 protein nm23 protein
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between expression of p53,nm23 and invasion and metastasis in human colorectal carcinoma,and the correlation between expression of p53 and nm23.Methods:Expression of p53 and nm23 were studied with SABC immunohistochemical technique Results:The positive rate of p53 and nm23 in 41 samples of human colorectal carcinoma was 58 5% and 53 7% respectively p53 over expression and nm23 low expression was significantly correlated with the depth of invasion and lymphatic metastasis The expression of p53 in pooly differentiated carcinoma was obviously higher than that in well differentiated carcinoma(P0 05) p53 over expression was correlated with nm23 low expression Conclusion:Over expression of p53 and low expression of nm23 might play an important role in invasion and metastasis of human colorectal carcinoma p53 over expression was related to the differentiation of colorectal carcinoma tissue
