The role of interleukin 6 and interleukin 6 receptor in gliomas
- VernacularTitle:IL6和IL6R在脑胶质瘤发病中的作用初探
- Author:
Yongsheng HU
;
Qinglin ZHANG
;
Zhigang TIAN
;
Al ET
- Publication Type:Journal Article
- Keywords:
glioma;
interleukin 6;
interleukin 6 receptor;
loop;
reverse transctription polymerase chain reaction
- From:China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To discuss the role of interleukin 6 (IL 6) and IL 6 receptor (IL 6R) in gliomas. Methods:We detected IL 6 and IL 6R gene in 30 human glioma tissue specimens and adult normal astrocytes. A complementary DNA copy of total RNA was synthesized and amplified with specific primers using the reverse transcription polymerase chain reaction (RT PCR) method. Results:IL 6 gene was positive of in 24 (80.0%) samples of gliomas, while IL 6R gene was positive of in 26 (86.7%) cases. Co expression of IL 6 and IL 6R was identified in 22 (73.3%) specimens of gliomas. On the other hand,the expression of IL 6 was weakly positive in adult normal astrocyte, but IL 6R was negative.Conclusions:Our results indicate that IL 6/IL 6R autocrine or paracrine loop may exist in glioma, which could enhance the glioma cell proliferation.
