High dose epirubicin containing combination regimen in the treatment of advanced breast cancer
- VernacularTitle:含大剂量表柔比星的联合化疗治疗晚期乳腺癌
- Author:
Guoqing HU
;
Bangshun HE
;
Weiguo HU
;
- Publication Type:Journal Article
- Keywords:
breast cancer;
epirubicin;
combination chemotherapy
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the efficacy and the toxic side effects of high dose epirubicin containing combination regimen in the treatment of advanced breast cancer. Methods:16 patients with advanced breast cancer were treated with epirubicin (EPI) 100 mg/m 2,CTX 600 mg/m 2,5 FU 500 mg/m 2,every 21 days,Each patient was given at least 2 cycles. Results:There were 2 CR and 9 PR, the overall response rate was 68.8% (11/16). Main side effects were grade Ⅰ—Ⅱ leucopenia, nausea and vomitting, alopecia.Conclusions:This study confirmed that combination chemotherapy with high dose epirubicin is a safe and effective regimen for patients with advanced breast cancer and is worthy of further clinical trial.
