Effect of exogenous P14ARF gene on the growth of human glioma cells
- VernacularTitle:外源型P14ARF基因对人脑胶质瘤细胞生长的影响
- Author:
Xianyun CAO
;
Xiaocheng CHEN
;
Nan GAO
;
Al ET
- Publication Type:Journal Article
- Keywords:
P14ARF;
glioma;
cell cycle;
tumor suppressor gene
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the effect of P14ARF gene on human glioma cell line (U 251) Methods:We transfected P14ARF gene into human malignant glioma cell line with liposomal transfection reagent, we assessed cell growth properties,cell cycle.Results:After successful transfection, the human malignant glioma cell line U 251 proliferation rate was slower. The cell cycle was suppressed at G 1 and G 2.Conclusions:The findings suggest that p14ARF gene may be able to inhibit the growth of glioma cell in vitro.
