The correlation between hEST2 reverse transcription motif and the activity of telomerase
- VernacularTitle:hEST2逆转录功能区片段与端粒酶活性相关性
- Author:
Hanneng ZHU
;
Suzhen MO
;
Weihua LUO
;
Al ET
- Publication Type:Journal Article
- Keywords:
telomerase;
hEST2;
reverse transcription motif
- From:China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:Telomerase was discovered recently as an important tumor marker, and the necessary gene sequence which is closely related with telomerase activity is one of the methods to study the telomerase regulation mechanism. Methods:RT PCR, Northern blot were used to test the relationship between the expression of hEST2 reverse transcriptase motif fragment and telomerase activity, classic telomerase measurement method was set up as contol. Results:Indicate that the expression of 7 RT motifs fragment which include telomerase specific T motif have a close relationship with telomerase activity. Conclusions:It will be helpful to further research of telomerase regulation mechanism, diagnosis and inhibition.
