STUDY ON THE EXPRESSION AND SIGNIFICANCE OF FAS AND FASL IN EPIDERMAL TUMORS
- VernacularTitle:Fas、FasL在表皮肿瘤中的表达及其意义
- Author:
Jianli WANG
;
Songhai GENG
;
- Publication Type:Journal Article
- Keywords:
Fas;
Fas Ligand;
Epidermal tumors;
Apoptosis
- From:
Cancer Research and Clinic
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between the expression of Fas,Fas Ligand and epidermal tumors' malignant degree.Methods:The immunohistochemical technique was employed to detect the expression of Fas and Fas Ligand in Bowens' disease,Squamous Cell Carcinoma(SCC)and Basal Cell Carcinoma(BCC).Results:The Fas and Fas Ligand could be detected in Bowens disease and SCC.The intensity of expression of Fas was downregulated and that of Fas Ligand was upregulated along with the maligant degree increasing of tumors.The expression of Fas,Fasl in BCC were lower than that in Bowens disease and SCC.Conclusion:The expression of Fas and Fas Ligand were correlated to malignant degree and clinical prognosis of some epidermal tumors,for abnormal apoptosis directed by contract of Fas and Fas Ligand may be one of the causes responsible to epidermal tumor's local immune escaping.
