Human ?-cells destruction correlates with Fas expression on ?-cells induced by IFN-? and TNF-?
- VernacularTitle:IFN-?和TNF-?诱导Fas表达在?胰岛细胞杀伤中的作用
- Author:
Huarong ZHOU
;
Ming LI
;
Yue ZHANG
;
Guanxin SHEN
;
Xinrong ZHOU
;
- Publication Type:Journal Article
- Keywords:
Fas Cytokine Apoptosis IDDT
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of increased expression of Fas on the killing of ? cells Methods:The level of Fas expression and apoptosis of human ? cells strain (NIT) were detected by FACS Results:There is no Fas expression on NIT But Fas expression can detected by culturing NIT with IFN ? and/or TNF ? The apoptosis of NIT induced by sFasL and anti Fas correlates with the level of Fas expression Conclusion:Fas expression induced by cytokine may represent a factor for the initiation of ? cells destruction
