EXPRESSION OF Rb AND p53 GENE IN GASTRIC CARCINOMAS IN RELATION TO PROGNOSIS
- VernacularTitle:Rb基因和p53基因表达与胃癌预后的关系
- Author:
Ning LI
;
Xiang DING
;
Zhizhong FAN
;
Qingfu ZHU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms Genes,retinoblastoma Gene,p53 in situ hybridization Lymphatic metastasis Prognosis
- From:
China Oncology
1999;0(Z1):-
- CountryChina
- Language:Chinese
-
Abstract:
PURPOSE Expression of Rb and p53 gene in gastric carcinomas and its relationship to prognosis as well as clinico pathology were investigated.METHODS Expression of Rb and p53 products and p53 gene mutation in gastric carcinomas were analysed by means of immunohistochemistry and in situ hybridazation.RESULTS p53 gene mutation was found in 6/20(30%).Over expression of Rb and p53 products was found in 62/85(72.94%) and 42/85(49.41%).Both the positive grades showed significant inverse correlation with patient survival( P
