EXPERIMENTAL RESEARCH OF EFFECT COMBINED WITH NEW RECOMBINANT HUMAN TUMOUR NECROSIS FACTOR AND ETOPOSIDE IN MURINE PNEUMOCELLULAR CARCINOMA
- VernacularTitle:新型基因工程人肿瘤坏死因子联合VP_(16)治疗小鼠肺癌的实验研究
- Author:
Xu ZHU
;
Chuning WANG
;
Huiping LONG
;
Al ET
- Publication Type:Journal Article
- Keywords:
nrhTNF;
VP_(16);
Lung cancer
- From:
Cancer Research and Clinic
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibitive effects of treatment with new recombinant humantumor necrosis factor (nrhTNF) and/or etoposide (VP16) on murine lung cancer. Methods Tumor-bearingmice were randomly divided into four groups. NS, nrhTNF, VP16, nrhTNF and VP16, were respectivelyinjected into endoneoplasm in every group. Results Inhibition rate in nrhTNF group and VP16 group were33.71 % and 30. 46% respectively and resulted in tumor necrosis to a certain degree. The number of lungmetastatic tumors in the mentioned groups above were less than that in control group (P
