THE ABNORMAL RELATIONSHIP OF EXPRESSION OF MTS_1/p16 GENE WITH THE BIOLOGICAL BEHAVIOR IN MALIGNANT TUMOR OF BILE DUCT
- VernacularTitle:MTS_1/p16基因异常表达与胆道恶性肿瘤生物学行为关系
- Author:
Guihe WANG
;
Tiejun ZHAO
;
Fei XIA
;
Al ET
- Publication Type:Journal Article
- Keywords:
Gallbladder cancer;
Bile duct cancer;
p16 gene
- From:
Cancer Research and Clinic
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression of p16 protein in malignant tumor of bile duct and itsrelationship with tumor behavior. Methods pl6 protein was studied by immunohistochemical method.Results The positive expression rate of MTS,/p16 in malignant tumor was lower than that in benign ones,and had close correlationship with the invasiveness and lymph nodes metastasis (P0.01 ). Conclusion The investigation of MTS1/p16 is of .great importance in evaluating the invasiveness of tumor, meta-potential of lymph node and clinicalprognosis.
