THE SIGNAL TRANSDUCTION OF APOPTOSIS INDUCED BY ADRIAMYCIN
- VernacularTitle:阿霉素诱导细胞凋亡过程中的信号传递
- Author:
Xiaoming JIN
;
Yincheng ZHANG
;
Yaxin LI
;
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Human salivary gland carcinom cell lines;
Signal transduction
- From:
Cancer Research and Clinic
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether or not driamycin inhibits mEC cells by apoptosis. MethodsAdriamycin was used for mucoepidermoid carcinoma cells mEC-l. Morphologic changes were observed atdifferent times by light and electronic microscope. DNA fragments were shown on agarose gelelectrophoresis. DNA content and cell cycles were analyzed by flow cytometer. Changes of intracellularcalcium ion was monitored by flow cytometer. Results mEC-1 cells presented with classic morphologicfeatures of apoptosis. Intracellular calcium ion was increased. Conclusion Apoptosis followed by thechanges of intracellular calcium ion in human salivary gland mucoepidermoid carcinoma cells is one of themechanisms of adriamycin inhibited tumor cell growth.
