Histopathologicai findings of Cyclosporine A induced hepatotoxicity and nephrotoxicity in laryngeal allograft recipients
- VernacularTitle:环孢素A对大鼠喉移植受体肝肾毒性作用——组织病理学观察
- Author:
Yong QING
;
Jibao WANG
;
Jinzhi CHEN
;
- Publication Type:Journal Article
- Keywords:
Cyclosporine A;
Nephrotoxicity;
Heptotxicity;
Histopathology
- From:
Chinese Journal of Organ Transplantation
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
By establishing experimental modal of laryngeal allograft,the short-term histopathological changes of liver and kidney in Cyclosporine A (CsA)-treated rats receiving laryn- geal allograft were observed.The animals were divided into 3 groups.Group 1 was given CsA 15 mg?kg~(-1)/d by daily intraperitoneal injection for 2 weeks,Group 2 received CsA 25 mg?kg~(-1)/d, and the third group without CsA treatment served as control.All of recipients were sacrificed 14 days after transplantation.Histological examination showed that CsA nephrotoxicity was charac- terized by abundant vacuolation of the proximal tubular epithelium cells,hyaline regeneration of arterioles with thickening of vascular wall,and striped interstitial fibrosis and its hepatotoxicity by fatty degeneration with mild hyperplasia of Kupffer's cells and focal necrosis of hepatocytes. Histopathological changes of CsA-induced hepato- and nephrotoxicity of the recipients were closely correlated to the dosage of CsA received.
