CHARGE SELECTIVITY OF PROTEINURIA IN DIABETES
- VernacularTitle:糖尿病性蛋白尿电荷选择性的研究
- Author:
Lin-Lang LIANG
;
Guo-Liang LIU
;
- Publication Type:Journal Article
- Keywords:
Nephropathy, diabetic Immunoglobulin G Immunoglobulin G4
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The clearance of proteins differing in charge and/or size (IgG4, total IgG and albumin) was evaluated in 95 diabetic patients. Urinary IgG4 values increased in group mi-croalbuminuria. The increased urinary IgG4 excretion correlated significantly with the degree of albuminuria and diabetic retinopathy. Urinary total IgG levels increased obviously only in group with massive macroalbuminuria. The IgG4/total IgG ratio was highest in group mi-croalbuminuria, and its change had a special pattern. Urinary IgG4 and IgG4/total IgG ratio may be sensitive parameters in assessing early protein charge-selectivity impairment and in detecting incipient diabetic nephropathy.
