A rat model of laryngeal ailotransplantation
- VernacularTitle:大鼠同种异体喉移植模型的建立
- Author:
Yong QIN
;
Jibao WANG
;
Jinzhi CHEN
;
Huisheng XIA
;
- Publication Type:Journal Article
- Keywords:
Laryngeal/transplantation;
Model;
Rat
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
A rat model of laryngeal allotransplantation was established by employing an end- to-side anastomosis of donor bilateral common carotid arteries to recipient common carotid artery and external jugular vein separatively.Thirteen allotransplants were performed in 26 SD rats.All recipients survived.Three days after the operation,a visible fibrinous adherence was observed around the laryngeal grafts.By the 7th day,the adherence became intensified.The airway was plugged with mucoid material,and the viable grafts were surrounded by connective tissues.Our results confirmed that the rat model was practicable for laryngeal allograft.Besides the difference of the major histocompatibility between the donor and recipient,the skill of microsurgery,the prevention of infections and the methods of donor organ flushing are all vital to a successful trans- plantation.
