THE EFFECT OF hCG STIMULATION GIVEN AT DIFFERENT INTERVIALS ON TESTOSTERONE BIOSYNTHESIS IN CULTURED HUMAN TESTICULAR TISSUE
- VernacularTitle:不同间隔时间人绒毛膜促性腺激素刺激对体外培养的人睾丸组织睾酮分泌的影响
- Author:
Jing-Tao DOU
;
Jiang-Yuan LI
;
Ai-Yan GUO
;
- Publication Type:Journal Article
- Keywords:
Human chorionic gonadotropin Tissue culture, testis Testosterone Desensitization
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Cultured human testicular tissues were grouped as follows:control group,group tracted with single dosc of human chorionic gonadotropin(hCG), group treated with double doses of hCG given at three-day-interval and group treated with multiple doses of hCG. The dose of hCG was 20kIU/L,and it was added into the medium and incubated for 24 hours. Testosterone was measured by RIA. The result indicated that all three hCG-treated groups had a testosterone secretion peak at 48-72 hours after the first dose of hCG. After the second hCG treatment given in three days interval the testosterone increased again. but its maximal rise reduced. Multiple doses of hCG given successively inhibited the response of Leydig cells to hCG stimulation.
